| Titel: | Exercise Effects on Depressive Symptoms in Cancer Survivors: A Systematic Review and Meta-Analysis |
|---|---|
| Autor: | Craft, L. L. Vaniterson, E. H. Helenowski, I. B. Rademaker, A. W. Courneya, K. S. |
| Mediengruppe: | journal article |
| Herausgeber: | --- |
| Zeitschrift: | Cancer Epidemiology Biomarkers & Prevention |
| Jahr: | 2012 |
| Band: | 21 |
| Heft: | 1 |
| Seiten: | 3-19 |
| Sprache: | English |
| Abstract: | Background: Depression is a distressing side effect of cancer and its treatment. In the general population, exercise is an effective antidepressant.; Objective: We conducted a systematic review and meta-analysis to determine the antidepressant effect of exercise in cancer survivors.; Data Sources: In May 2011, we searched MEDLINE, PsycInfo, EMBASE, CINAHL, CDSR, CENTRAL, AMED, Biosis Previews, and Sport Discus and citations from relevant articles and reviews.; Study Eligibility Criteria: We included randomized controlled trials (RCT) comparing exercise interventions with usual care in cancer survivors, using a self-report inventory or clinician rating to assess depressive symptoms, and reporting symptoms pre- and postintervention.; Study Appraisal: Around 7,042 study titles were identified and screened, with 15 RCTs included.; Synthesis Methods: Effect sizes (ES) were reported as mean change scores. The Q test was conducted to evaluate heterogeneity of ES. Potential moderator variables were evaluated with examination of scatter plots and Wilcoxon rank-sum or Kruskal-Wallis tests.; Results: The overall ES, under a random-effects model, was -0.22 (confidence interval, -0.43 to -0.09; P = 0.04). Significant moderating variables (ps < 0.05) were exercise location, exercise supervision, and exercise duration.; Limitations: Only one study identified depression as the primary endpoint.; Conclusions: Exercise has modest positive effects on depressive symptoms with larger effects for programs that were supervised or partially supervised, not conducted at home, and at least 30 minutes in duration.; Impact: Our results complement other studies showing that exercise is associated with reduced pain and fatigue and with improvements in quality of life among cancer survivors. Cancer Epidemiol Biomarkers Prev; 21(1); 3-19. (C) 2011 AACR. |