| Titel: | Behavioral, Emotional, and Cognitive Sequelae of Immune System Activation |
|---|---|
| Autor: | Hash-Converse, Joanne M. Kusnecov, Alexander W. |
| Mediengruppe: | chapter |
| Herausgeber: | --- |
| Zeitschrift: | --- |
| Jahr: | 2011 |
| Band: | --- |
| Heft: | --- |
| Seiten: | 65-76 |
| Sprache: | English |
| Abstract: | (from the chapter) Stress is commonly conceptualized from the perspective of psychogenic origins. However, stress can also arise from changes in physiological states (termed systemic stress), particularly during immune system (IS) activation. This conceptualization arose within the field of psychoneuroimmunology (PNI), which investigates mind-body interactions through the meditational role of the IS. Briefly, some major lines of evidence for the so-called "immune-to-brain" pathway include: (i) immune products influence neurotransmitter activity, (ii) cytokine receptors are found in the brain, and (iii) many psychiatric disorders parallel autoimmune development and pathology. As we discuss further in the following text, a full understanding of this complex relationship has yet to be achieved and, in particular, the behavioral and affective sequelae of immune activation—especially in human subjects—have yet to be delineated. In what follows, we will endeavor to examine how immune activation serves as a systemic stressor to influence behavior and emotional states, and to specify what the implications of this activation are for mental and physical health. The summaries in this chapter are intended to provide the basic framework from which to conceptualize the effect of immune activation on behavior. In addition, because there is copious evidence for the effect of the CNS on immune activity, the present discussion will focus on how the IS acts as a systemic stressor to influence CNS function and behavior. (PsycINFO Database Record (c) 2012 APA, all rights reserved) (chapter) |