| Titel: | Cognition and fatigue in multiple sclerosis: Potential effects of medications with central nervous system activity |
|---|---|
| Autor: | Oken, BS Flegal, K Zajdel, D Kishiyama, SS Lovera, J Bagert, B Bourdette, DN |
| Mediengruppe: | journal article |
| Herausgeber: | --- |
| Zeitschrift: | Journal of Rehabilitation Research and Development |
| Jahr: | 2006 |
| Band: | 43 |
| Heft: | 1 |
| Seiten: | 83-90 |
| Sprache: | English |
| Abstract: | To evaluate the potential effects of medications with central nervous system (CNS) activity on cognitive function and fatigue in multiple sclerosis (MS), we performed a retrospective analysis of medication use among 70 subjects with MS who were participating in a clinical trial for evaluation of the effects of yoga and exercise programs on cognition and fatigue. Among these MS subjects, 74% were taking at least one potentially CNS-active medication. These 70 subjects were divided into two groups: those taking at least one CNS-active medication (n = 52) and those not on any medications with potential CNS activity (n = 18). We compared assessments of cognitive function and fatigue using an analysis of covariance. MS subjects on CNS-active medication had greater impairment on measures of processing speed, sustained attention, and fatigue than those not on these medications. While these findings do not establish a causal relationship between medication use and cognitive impairment and fatigue, the data indicate that researchers need to control for use of CNS-active medications when conducting studies of cognitive impairment and fatigue in MS subjects. |